RNAi Development

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RNAi Development

In a recent contribution to PLoS Computational Biology, Cannarozzi, Schneider, and Gonnet published evidence that rodents form an outgroup to human and dog [1], in disagreement with several recent studies suggesting that the dog is an outgroup to the primate–rodent clade [2,3]. The authors’ arguments rest on a variety of analyses of human, mouse, and dog genes, using opossum to root the phyloge...

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Development of RNAi in Insects and RNAi-Based Pest Control

In agricultural systems, insect pests can cause crop damage mainly through loss in yield or quality resulting in a loss in profits for farmers. Worldwide pests cost billions of dollars due to damage and use of pesticides. Chemical pesticides are still the major approach for controlling insect pests, but they are associated with significant hazards to the environment and human health. The altern...

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Development of new RNAi therapeutics.

RNAi-mediated gene inactivation has become a cornerstone of the present day gene function studies that are the foundation of mechanism and target based drug discovery and development, which could potentially shorten the otherwise long process of drug development. In particular, the coming of age of "RNAi drug" could provide new promising therapeutics bypassing traditional approaches. However, t...

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Development of RNAi Methods for Peregrinus maidis, the Corn Planthopper

The corn planthopper, Peregrinus maidis, is a major pest of agronomically-important crops. Peregrinus maidis has a large geographical distribution and transmits Maize mosaic rhabdovirus (MMV) and Maize stripe tenuivirus (MSpV). The objective of this study was to develop effective RNAi methods for P. maidis. Vacuolar-ATPase (V-ATPase) is an essential enzyme for hydrolysis of ATP and for transpor...

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Development of an RNAi based microalgal larvicide to control mosquitoes

1 Donald Danforth Plant Science Center 975 N. Warson Rd, St. Louis, MO 63132, USA 2 Department of Plant Cellular and Molecular Biology, The Ohio State University, Columbus, OH 43210, USA 3 Current address, Logos Procyte, 1005 N. Warson Rd., Suite B01, St Louis, MO 63132, USA 4 Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA 5 New Mexico Consortium, Los Ala...

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ژورنال

عنوان ژورنال: PLoS Computational Biology

سال: 2007

ISSN: 1553-7358

DOI: 10.1371/journal.pcbi.0030080